Least sedating benzodiazepine

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All anticholinergics used in the management of vertigo have prominent side effects of dry mouth, dilated pupils, and sedation.

least sedating benzodiazepine-39least sedating benzodiazepine-89

Withdrawal has been described from a similar agent to meclizine, diphenhydramine. With the possible exception of astemizole (Hismanal) in Meniere's disease (Turner and Jackson, 1989), antihistamines that do not cross the blood brain barrier, are not used to control vertigo.

Unfortunately, astemizole does not appear to be generally useful as it is ineffective in preventing motion sickness (Kohl et al, 1987) and because it has significant potential toxicity.

There are also some reports of scopolamine inducing migraine, as well as a withdrawall syndrome.

There is no reason to believe that any one nonselective ACH antagonist (e.g.

The atrophine derivitive, hyocyamine (L-atropine), can be used instead.

Cholinergic agonists that cross into the brain, such as physostigmine, can cause a motion-sickness syndrome (Soto et al, 2013).H1 receptors are present in guinea pig vestibular nucleus, but they don't seem to be relevant to vertigo, and it does not appear that the therapeutic effects of H1 receptor blockers can be attributed to blockate of H1 (Timmerman, 1994).H3 receptor agonists appear to cause the same result as blockade of H2 receptors.To learn more or modify/prevent the use of cookies, see our Cookie Policy and Privacy Policy. We also highly recommend the neuropharmacology review article written by Soto et al (2013).Scopolamine and atropine are nonspecific muscarinic receptor antagonists (Barton et al, 1994; Soto et al, 2013).

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